Correlation between Expression of Peripheral IL-17 Protein and Aggression of Bipolar Mania / 法医学杂志
Journal of Forensic Medicine
; (6): 40-44, 2016.
Article
de Zh
| WPRIM
| ID: wpr-984040
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE@#To explore the correlation between the interleukin-17 (IL-17) level of peripheral blood and aggression of bipolar mania.@*METHODS@#Thirty-six patients of bipolar mania were selected as experimental group by DSM-IV-TR and received treatment with quetiapine and lithium. Thirty-six healthy volunteers with similar age and gender were selected as control group. The level of IL-17 at baseline in each group and the level of IL-17 in the experimental group after treatment for 2, 4 and 8 weeks were detected by ELISA.@*RESULTS@#The level of IL-17 in experimental group at baseline, after treatment for 2 and 4 weeks were all significantly higher than that in control group. After 8 weeks treatment, there was no significant difference between the two groups (P > 0.05). After 2, 4 and 8 weeks treatment, the total score and aggression score of Young Mania Rating Score (YMRS) were significantly lower than the baseline level (P < 0.05). In experimental group, the level of IL-17 was positively correlated with the two scores of YMRS at baseline (P < 0.05).@*CONCLUSION@#Bipolar mania may be related to the up-regulation of IL-17. The level of IL-17 is related to the severity of manic symptoms at baseline, especially aggression symptom.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Neuroleptiques
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Trouble bipolaire
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Marqueurs biologiques
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Études cas-témoins
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Méthode en double aveugle
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Résultat thérapeutique
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Composés du lithium
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Interleukine-17
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Diagnostic and stastistical manual of mental disorders (USA)
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Agressivité
Limites du sujet:
Humans
langue:
Zh
Texte intégral:
Journal of Forensic Medicine
Année:
2016
Type:
Article