Pathogenic Role of Autophagy in Rheumatic Diseases
Journal of Rheumatic Diseases
;
: 202-211, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-98412
ABSTRACT
Autophagy is a principle catabolic process mediated by lysosomes in eukaryotic cells. This is an intracellular homeostatic mechanism crucial for degradation in acidic lysosomal compartments of waste components from the cytoplasm. Autophagy research was initially focused on its degradation mechanism, but focus is now shifting to its effects on immunity. It contributes to detection and removal of pathogens as well as regulation of inflammasomes and neutrophil extracellular traps. Moreover, it is pivotal in antigen presentation and immune cell maturation, survival and homeostasis. The importance of autophagic pathways in normal and dysregulated immunity has become increasingly recognized in the past several years. Dysregulation of the autophagic pathway is implicated in the pathogenesis of several rheumatic diseases. In this review, we summarize the immunological function of autophagy in innate and adaptive immunity, and the functions of autophagy in the pathogenesis of rheumatic diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Polyarthrite rhumatoïde
/
Autophagie
/
Rhumatismes
/
Présentation d'antigène
/
Cytoplasme
/
Cellules eucaryotes
/
Immunité acquise
/
Inflammasomes
/
Pièges extracellulaires
/
Homéostasie
langue:
Anglais
Texte intégral:
Journal of Rheumatic Diseases
Année:
2016
Type:
Article
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