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The Change of HBV DNA Titer after Hepatic Resection in Hepatitis B Patients with Hepatocelluar Carcinoma
Korean Journal of Hepato-Biliary-Pancreatic Surgery ; : 16-24, 2010.
Article Dans Coréen | WPRIM | ID: wpr-98600
ABSTRACT

PURPOSE:

Reactivation of hepatitis B virus (HBV) replication after hepatic resection might be a significant risk factor for prognosis in patients with chronic hepatitis B. The purpose of the present study was to investigate the changing pattern of serum HBV DNA titer after hepatic resection and to assess the incidence of reactivation of HBV replication.

METHODS:

Among HBV-positive patients who underwent hepatic resection for hepatocellular carcinoma, thirty-six patients with preoperative serum HBV DNA titer > or =3 log(10)copies/mL were enrolled. Serum DNA titers were examined before the operation, on the second and seventh postoperative days, and one month after the operation.

RESULTS:

The serum DNA titer decreased on the second postoperative day (p=0.078). The DNA level, however, had substantially returned to preoperative values by the seventh postoperative day (p<0.001). For most patients, the postoperative DNA titer reached its zenith on the seventh postoperative day or one month after the operation. The zenith level was higher (by 0.49+/-0.25 log10copies/mL) than preoperative levels although this difference just missed significance (p=0.068). Although postoperative reactivation of HBV replication emerged in 6 patients, only one of those patients developed postoperative hepatitis. Overall, four patients developed postoperative hepatitis and all of them had high postoperative HBV DNA levels (over 6 log(10)copies/mL).

CONCLUSION:

Although serum HBV DNA titers tended to increase postoperatively, routine antiviral therapy might be unnecessary because of the low incidence of postoperative hepatitis. High postoperative DNA levels, however, might be a risk factor for hepatitis, and postoperative follow-up of serum HBV DNA levels might be necessary in HBV-positive patients with hepatic resection.
Sujets)

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / ADN / Virus de l&apos;hépatite B / Incidence / Facteurs de risque / Études de suivi / Carcinome hépatocellulaire / Hépatite B chronique / Réplication de l&apos;ADN / Hépatectomie Type d'étude: Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains langue: Coréen Texte intégral: Korean Journal of Hepato-Biliary-Pancreatic Surgery Année: 2010 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pronostic / ADN / Virus de l&apos;hépatite B / Incidence / Facteurs de risque / Études de suivi / Carcinome hépatocellulaire / Hépatite B chronique / Réplication de l&apos;ADN / Hépatectomie Type d'étude: Etude d'étiologie / Etude d'incidence / Étude observationnelle / Étude pronostique / Facteurs de risque Limites du sujet: Humains langue: Coréen Texte intégral: Korean Journal of Hepato-Biliary-Pancreatic Surgery Année: 2010 Type: Article