Post-treatment Effects of Erythropoietin and Nordihydroguaiaretic Acid on Recovery from Cisplatin-induced Acute Renal Failure in the Rat
Journal of Korean Medical Science
; : S170-S175, 2009.
Article
de En
| WPRIM
| ID: wpr-98681
Bibliothèque responsable:
WPRO
ABSTRACT
5-Lipoxygenase inhibitor and human recombinant erythropoietin might accelerate renal recovery in cisplatin-induced acute renal failure rats. Male Sprague-Dawley rats were randomized into four groups: 1) normal controls; 2) Cisplatin group-cisplatin induced acute renal failure (ARF) plus vehicle treatment; 3) Cisplatin+nordihydroguaiaretic acid (NDGA) group-cisplatin induced ARF plus 5-lipoxygenase inhibitor treatment; 4) Cisplatin+erythropoietin (EPO) group-cisplatin induced ARF plus erythropoietin treatment. On day 10 (after 7 daily injections of NDGA or EPO), urea nitrogen and serum Cr concentrations were significantly lower in the Cisplatin+NDGA and Cisplatin+EPO groups than in the Cisplatin group, and 24 hr urine Cr clearances were significantly higher in the Cisplatin+EPO group than in the Cisplatin group. Semiquantitative assessments of histological lesions did not produce any significant differences between the three treatment groups. Numbers of PCNA(+) cells were significantly higher in Cisplatin, Cisplatin+NDGA, and Cisplatin+EPO groups than in normal controls. Those PCNA(+) cells were significantly increased in Cisplatin+NDGA group. These results suggest that EPO and also NDGA accelerate renal function recovery by stimulating tubular epithelial cell regeneration.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Régénération
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Azote uréique sanguin
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Arachidonate 5-lipoxygenase
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Masoprocol
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Érythropoïétine
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Cisplatine
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Rat Sprague-Dawley
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Créatinine
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Cellules épithéliales
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Atteinte rénale aigüe
Limites du sujet:
Animals
langue:
En
Texte intégral:
Journal of Korean Medical Science
Année:
2009
Type:
Article