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An interpretable machine learning-based prediction model for risk of death for patients with ischemic stroke in intensive care unit / 南方医科大学学报
Journal of Southern Medical University ; (12): 1241-1247, 2023.
Article Dans Chinois | WPRIM | ID: wpr-987041
ABSTRACT
OBJECTIVE@#To construct an inherent interpretability machine learning model as an explainable boosting machine model (EBM) for predicting one-year risk of death in patients with severe ischemic stroke.@*METHODS@#We randomly divided the data of 2369 eligible patients with severe ischemic stroke in the MIMIC-Ⅳ(2.0) database, who were admitted in ICU in 2008 to 2019, into a training dataset (80%) and a test dataset (20%), and assessed the prognosis of the patients using the EBM model. The prediction performance of the model was evaluated by calculating the area under the receiver operating characteristic (AUC) curve. The calibration curve and Brier score were used to evaluate the degree of calibration of the model, and a decision curve was generated to assess the net clinical benefit.@*RESULTS@#The EBM model constructed in this study had good discrimination power, calibration and net benefit, with an AUC of 0.857 (95% CI 0.831-0.887) for predicting prognosis of severe ischemic stroke. Calibration curve analysis showed that the standard curve of the EBM model was the closest to the ideal curve. Decision curve analysis showed that the model had the greatest net benefit rate at the prediction probability threshold of 0.10 to 0.80. The top 5 independent predictive variables based on the EBM model were age, SOFA score, mean heart rate, mechanical ventilation, and mean respiratory rate, whose significance scores ranged from 0.179 to 0.370.@*CONCLUSION@#This EBM model has a good performance for predicting the risk of death within one year in patients with severe ischemic stroke and allows clinicians to better understand the contributing factors of the patients' outcomes through the model interpretability.
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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Calibrage / Bases de données factuelles / Apprentissage machine / Accident vasculaire cérébral ischémique / Unités de soins intensifs Limites du sujet: Humains langue: Chinois Texte intégral: Journal of Southern Medical University Année: 2023 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Calibrage / Bases de données factuelles / Apprentissage machine / Accident vasculaire cérébral ischémique / Unités de soins intensifs Limites du sujet: Humains langue: Chinois Texte intégral: Journal of Southern Medical University Année: 2023 Type: Article