Lack of Replication of Genetic Association with Body Mass Index Detected by Genome-wide Association Study
Genomics & Informatics
;
: 59-63, 2011.
Article
Dans Anglais
| WPRIM
| ID: wpr-98932
ABSTRACT
Obesity provokes many serious human diseases, including various cardiovascular diseases and diabetes. Body mass index (BMI) is a highly heritable trait that is broadly used to diagnose obesity. To identify genetic loci associated with obesity in Asians, we conducted a genome-wide association study (GWAS) of a population of Korean adults (n=6,742, age 40~60 years) and detected six BMI risk loci (TNR, FAM124B, RGS12, NFE2L3, MC4R and FTO) having p<1x10(-5). However, in the replication study, only melanocortin 4 receptor gene (MC4R) (rs9946888, p=4.58x10(-7)) was replicated with marginal significance (p<0.05) in the second cohort (n=5,102, age 40~60 years). This study indicates that each locus associated with BMI has very weak genetic effect.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Maladies cardiovasculaires
/
Indice de masse corporelle
/
Études de cohortes
/
Récepteur de la mélanocortine de type 4
/
Asiatiques
/
Étude d'association pangénomique
/
Locus génétiques
/
Obésité
Type d'étude:
Etude d'étiologie
/
Etude d'incidence
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Humains
langue:
Anglais
Texte intégral:
Genomics & Informatics
Année:
2011
Type:
Article
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