Advances of bioactive peptides in hepatic ischemia/reperfusion injury / 国际外科学杂志

ABSTRACT

Hepatic ischemia/reperfusion injury (HIRI) occurs in liver surgical interventions or systemic hemorrhagic shock, especially in liver transplantation, which can lead to serious postoperative complications and strongly threats the utilization of marginal donor livers and the prognosis of recipients. Here, how to effectively intervene HIRI has always been the important topic in liver surgery. The pathogenesis of HIRI has been gradually elucidated, but no effective prevention and treatment measures have been performed to reduce the injury in clinic. Peptides are small molecules without a quaternary protein structure, which can effectively regulate physiological processes such as stress and metabolism in the body, and participate in the occurrence and development of diseases. Recently, with the successful application of insulin and other peptides in the bedside, the effect of bioactive peptides on HIRI has been attracting wide attention, numbers of studies have confirmed that bioactive peptides have great potential for liver protection during HIRI. This article reviews the roles of bioactive peptides in HIRI and provides new sight and reference to protect liver from HIRI.