Historical control data from 13-week repeated toxicity studies in Crj:CD (SD) rats / 한국실험동물학회지
Laboratory Animal Research
; : 115-121, 2012.
Article
Dans En
| WPRIM
| ID: wpr-98979
Responsable en Bibliothèque :
WPRO
ABSTRACT
Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 13-week repeated toxicity studies in Crl:CD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 11 toxicity studies in 220 Crl:CD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 5 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gamma-glutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Taille d'organe
/
Valeurs de référence
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Entorses et foulures
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Toxicologie
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Utérus
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Granulocytes basophiles
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Bilirubine
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Poids
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Examen des urines
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Granulocytes éosinophiles
Limites du sujet:
Animals
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Humans
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Male
langue:
En
Texte intégral:
Laboratory Animal Research
Année:
2012
Type:
Article