Research progress on the relationship between Ferroptosis and renal ischemia-reperfusion injury / 中国医师杂志

ABSTRACT

Ferroptosis is a new type of programmed cell death, which is different from apoptosis, pyrodeath, necrosis and autophagy. It is characterized by the imbalance of cell iron homeostasis, which leads to the accumulation of reactive oxygen species and lipid peroxides, which exceeds the antioxidant capacity of cells and eventually leads to oxidative death of cells. Studies have shown that ferroptosis plays an important role in acute renal injury induced by renal ischemia-reperfusion and inhibition of ferroptosis can effectively alleviate renal ischemia-reperfusion injury. It is of great significance to study the relationship and mechanism of ferroptosis and renal ischemia-reperfusion injury to prevent acute renal function injury caused by renal ischemia-reperfusion injury in clinical work .