The clinical characteristics of hypertriglyceridemic pancreatitis and the correlation between triglyceride levels and the severity of severe acute pancreatitis / 中国医师杂志

ABSTRACT

Objective:To explore the clinical characteristics of hypertriglyceridemic pancreatitis and the correlation between triglyceride (TG) levels and the severity of severe acute pancreatitis (SAP).Methods:A retrospective analysis was conducted on the clinical data of 132 SAP patients admitted to Beijing Friendship Hospital of Capital Medical University from January 2020 to December 2021. They were divided into biliary acute pancreatitis (BAP) group, hypertriglyceridemic pancreatitis (HTGP) group, and alcohol-induced acute pancreatitis (AAP) group based on their etiology. The clinical data and laboratory test results of each group were compared, and the correlation between TG levels and the severity of SAP disease was analyzed.Results:The proportion of male patients, body mass index, length of hospital stay, ICU occupancy rate, C-reactive protein (CRP), TG, and total cholesterol (TC) levels in the HTGP group were significantly higher than those in the BAP and AAP groups. The age of onset, serum calcium (Ca), oxygenation index (PaO 2/FiO 2, P/F), and prothrombin time activity (PTA) in the HTGP group were significantly lower than those in the BAP and AAP groups, and the differences were statistically significant (all P<0.05). There was a negative correlation between TG levels and Ca, P/F, PTA in SAP patients ( r=-0.410, -0.341, -0.365, all P<0.01). Receiver operating characteristic (ROC) curve analysis showed that the area under the curve (AUC) of TG for early prediction of multiple organ dysfunction in SAP patients was 0.868, with a sensitivity of 87% and a specificity of 78%. Conclusions:Patients in the HTGP group have a lower onset age, with more males, obese patients, and critically ill patients. Laboratory indicators such as CRP, TG, and TC levels are higher, while levels of Ca, P/F, and PTA are lower; The serum TG level is correlated with the severity of SAP disease and can be used as one of the early indicators for predicting multiple organ dysfunction in SAP.