Research progress of exocrine non-coding RNA in cholangiocarcinoma / 中华肝胆外科杂志

ABSTRACT

Cholangiocarcinoma is the second most common malignant tumor in primary liver tumors, which has high malignant degree and poor prognosis. At present, there is no satisfactory and effective treatment method. Exosomes from various cells carry a variety of substances and act on the receptor cells, transmitting biological messages between different cells to regulate a variety of physiological and pathological changes. Exosomes can affect the tumor microenvironment and further mediate the tumorigenesis and progression of tumors via multiple approaches. Increasing studies have demonstrated that the non-coding RNA (ncRNAs) carried by tumor-derived exosomes is involved in regulating the occurrence, development and metastasis of cholangiocarcinoma. Combined with the current research progress, this article summarizes the role, diagnosis and treatment value of exosome ncRNAs in cholangiocarcinoma, so as to provide references for follow-up research.