A Comparison of Substantia Nigra T1 Hyperintensity in Parkinson's Disease Dementia, Alzheimer's Disease and Age-Matched Controls: Volumetric Analysis of Neuromelanin Imaging
Korean Journal of Radiology
; : 633-640, 2016.
Article
de En
| WPRIM
| ID: wpr-99440
Bibliothèque responsable:
WPRO
ABSTRACT
OBJECTIVE: Neuromelanin loss of substantia nigra (SN) can be visualized as a T1 signal reduction on T1-weighted high-resolution imaging. We investigated whether volumetric analysis of T1 hyperintensity for SN could be used to differentiate between Parkinson's disease dementia (PDD), Alzheimer's disease (AD) and age-matched controls. MATERIALS AND METHODS: This retrospective study enrolled 10 patients with PDD, 18 patients with AD, and 13 age-matched healthy elderly controls. MR imaging was performed at 3 tesla. To measure the T1 hyperintense area of SN, we obtained an axial thin section high-resolution T1-weighted fast spin echo sequence. The volumes of interest for the T1 hyperintense SN were drawn onto heavily T1-weighted FSE sequences through midbrain level, using the MIPAV software. The measurement differences were tested using the Kruskal-Wallis test followed by a post hoc comparison. RESULTS: A comparison of the three groups showed significant differences in terms of volume of T1 hyperintensity (p < 0.001, Bonferroni corrected). The volume of T1 hyperintensity was significantly lower in PDD than in AD and normal controls (p < 0.005, Bonferroni corrected). However, the volume of T1 hyperintensity was not different between AD and normal controls (p = 0.136, Bonferroni corrected). CONCLUSION: The volumetric measurement of the T1 hyperintensity of SN can be an imaging marker for evaluating neuromelanin loss in neurodegenerative diseases and a differential in PDD and AD cases.
Mots clés
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Maladie de Parkinson
/
Mésencéphale
/
Substantia nigra
/
Imagerie par résonance magnétique
/
Études rétrospectives
/
Maladies neurodégénératives
/
Syndromes parkinsoniens
/
Démence
/
Maladie d'Alzheimer
Type d'étude:
Observational_studies
Limites du sujet:
Aged
/
Humans
langue:
En
Texte intégral:
Korean Journal of Radiology
Année:
2016
Type:
Article