Expression of TGF-alpha, beta1, beta2 in Pterygial Mast cell
Journal of the Korean Ophthalmological Society
;
: 1261-1268, 2002.
Article
Dans Coréen
| WPRIM
| ID: wpr-99454
ABSTRACT
PURPOSE:
To evaluate whether TGF-alpha, beta1, beta2 are expressed in pterygial mast cell and the difference between each growth factor exists.METHODS:
We prepared 10 pieces each of excised normal conjunctiva, primary pterygium, recurrent pterygium from human eyes and then fixed those in 4% paraformaldehyde solution. The tissues were embedded in paraffin and slide samples taken from those. After that, we observed mast cells stained by immunohistochemistry against each of TGF-alpha,beta1 ,beta2 and compared the staining features between them, and we also confirmed metachromatic staining of the mast cell with toluidine blue.RESULTS:
As compared with normal conjunctiva, in primary and recurrent pterygia, those counts of mast cells expressing TGF-alpha, beta1, beta2 were increased respectively with statistical significance and especially, those counts for TGF-beta1 in primary pterygium were 9 times as high as in normal conjunctiva.CONCLUSIONS:
Pterygial mast cells are considered to play an important role in fibrovascular proliferation of pterygium by synthesizing and secretion of TGF-alpha, beta1, beta2 . Especially, TGF-beta1 is thought to play a more important role than TGF-alphaandbeta2 in primary pterygium.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Paraffine
/
Chlorure de tolonium
/
Ptérygion
/
Immunohistochimie
/
Facteur de croissance transformant alpha
/
Conjonctive
/
Facteur de croissance transformant bêta-1
/
Mastocytes
Limites du sujet:
Humains
langue:
Coréen
Texte intégral:
Journal of the Korean Ophthalmological Society
Année:
2002
Type:
Article
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