The role of H1- and H2-receptors in the effect of compound 48/80 in the asphyxiation and body temperature of mice
Yonsei Medical Journal
;
: 97-103, 1996.
Article
Dans Anglais
| WPRIM
| ID: wpr-99934
ABSTRACT
Contribution of histamine H1- and H2-receptors to the effect of compound 48/80, a potent histamine releaser, upon asphyxiation and body temperature in mice was investigated in the present experiments. Compound 48/80 showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Compound 48/80 also decreased the body temperature, which was in relation with the antihypoxic effect. Both the H1-receptor antagonist, dimethindene, and the H2-receptor antagonist, ranitidine, attenuated the hypothermic effect of compound 48/80, indicating the involvement of central histamine through both the H1- and H2-receptors. Ranitidine had no effect on the protective effect of compound 48/80 against hypoxia-induced lethality, whereas dimethindene completely antagonized it. These results suggest that the protective effect of compound 48/80 against hypoxia is mediated through histamine H1-receptors and is not related to its ability to induce hypothermia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Crises épileptiques
/
Température du corps
/
Récepteur histaminergique H1
/
Récepteur histaminergique H2
/
4-Méthoxyphénéthyl-méthyl-amine
/
Animaux
/
Hypoxie
/
Souris de lignée BALB C
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Yonsei Medical Journal
Année:
1996
Type:
Article
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