Radiolytic studies of cefozopran hydrochloride in the solid state
Electron. j. biotechnol
;
25: 28-32, ene. 2017. tab, graf, ilus
Artigo
em Inglês
| LILACS
| ID: biblio-1008389
ABSTRACT
Background: The radiation sterilization is one of the best methods for sterilizing vulnerable degradation drugs like cefozopran hydrochloride. Results: Chemical stability of radiosterylized cefozopran hydrochloride, was confirmed by spectrophotometric and chromatographic methods. EPR studies showed that radiation has created some radical defects whose concentration was no more than several dozen ppm. The antibacterial activity of cefozopran hydrochloride irradiated with a dose of 25 kGy was unaltered for Gram-positive bacteria but changed for two Gram-negative strains. The radiation sterilized cefozopran hydrochloride was not in vitro cytotoxic against human CCD39Lu normal lung fibroblast cell line. Conclusions: Cefozopran hydrochloride in solid state is not resistant to radiation sterilization and this method cannot be used for sterilization of this compound.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Cefalosporinas
/
Antibacterianos
Idioma:
Inglês
Revista:
Electron. j. biotechnol
Assunto da revista:
Biotecnologia
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Polônia
Instituição/País de afiliação:
Medical University of Lublin/PL
/
Polish Academy of Sciences/PL
/
Poznan University of Life Sciences/PL
/
Poznan University of Medical Sciences/PL
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