Galectin 3: an extraordinary multifunctional protein in dermatology. Current knowledge and perspectives
An. bras. dermatol
;
94(3): 348-354, May-June 2019. tab
Artigo
em Inglês
| LILACS
| ID: biblio-1011117
ABSTRACT
Abstract: Galectin 3 is a unique ~31 kDa protein that recognizes the N-acetyl-lactosamine structure of several glycoconjugates. It mainly occurs in epithelial and myeloid cells, but is also found in a variety of human cell types. In view of the crucial role played by galectin 3 in the regulation of cellular processes of essential importance and in the pathogenetic mechanisms of diverse disorders, it is not surprising that, particularly in the last three decades, the attention of the scientific community has been increasingly drawn to this extraordinary and multifunctional galectin. In this paper the authors summarize current knowledge on the expression of galectin 3 in normal and diseased human skin, its implications in the pathogenesis, diagnosis and prognosis of cutaneous disorders, and the perspectives of a novel approach to the treatment of the latter using galectin 3 or its inhibitors/antagonists.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Galectina 3
/
Dermatite
Limite:
Humanos
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Chipre
/
Grécia
Instituição/País de afiliação:
Center for Dermatologic Diseases/CY
/
Patras University/GR
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