Telomere length and childhood trauma in Colombians with depressive symptoms
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
;
41(3): 194-198, May-June 2019. tab
Artigo
em Inglês
| LILACS
| ID: biblio-1011493
ABSTRACT
Objective:
Childhood trauma and telomere length (TL) are important risk factors for major depressive disorder. We examined whether there was an association between childhood trauma and TL in a sample of Colombians who were assessed for depressive symptoms.Methods:
We applied the Center for Epidemiologic Studies Depression scale, the Patient Health Questionnaire-9, the Hospital Anxiety and Depression scale and the Childhood Trauma Questionnaire to 92 Colombian subjects (mean age = 21). TL was measured with quantitative PCR. Spearman's correlation coefficient (rs) was used to analyze the relationship between childhood trauma scores and TL.Results:
We found a significant correlation between TL and sexual abuse scores (rs = 0.428, p = 0.002) in individuals with higher depressive symptom scores.Conclusion:
This is the first report of a significant association between TL and sexual abuse in a Latin American sample and provides additional evidence about the role of childhood trauma and TL in neuropsychiatric disorders.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Maus-Tratos Infantis
/
Telômero
/
Transtorno Depressivo Maior
/
Encurtamento do Telômero
Tipo de estudo:
Estudo diagnóstico
/
Pesquisa qualitativa
/
Fatores de risco
Limite:
Criança
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Colômbia
Idioma:
Inglês
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Colômbia
/
Espanha
Instituição/País de afiliação:
Universidad Antonio Nariño/CO
/
University of Barcelona/ES
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