Elevated serum Activin A in chronic obstructive pulmonary disease with skeletal muscle wasting
Clinics
;
74: e981, 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1011918
ABSTRACT
OBJECTIVE:
Muscle wasting contributes to the reduced quality of life and increased mortality in chronic obstructive pulmonary disease (COPD). Muscle atrophy in mice with cachexia was caused by Activin A binding to ActRIIB. The role of circulating Activin A leading to muscle atrophy in COPD remains elusive.METHODS:
In the present study, we evaluated the relationship between serum levels of Activin A and skeletal muscle wasting in COPD patients. The expression levels of serum Activin A were measured in 78 stable COPD patients and in 60 healthy controls via ELISA, which was also used to determine the expression of circulating TNF-α levels. Total skeletal muscle mass (SMM) was calculated according to a validated formula by age and anthropometric measurements. The fat-free mass index (FFMI) was determined as the fat-free mass (FFM) corrected for body surface area.RESULTS:
Compared to the healthy controls, COPD patients had upregulated Activin A expression. The elevated levels of Activin A were correlated with TNF-α expression, while total SMM and FFMI were significantly decreased in COPD patients. Furthermore, serum Activin A expression in COPD patients was negatively associated with both FFMI and BMI.CONCLUSION:
The above results showed an association between increased circulating Activin A in COPD patients and the presence of muscle atrophy. Given our previous knowledge, we speculate that Activin A contributes to skeletal muscle wasting in COPD.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Atrofia Muscular
/
Doença Pulmonar Obstrutiva Crônica
/
Ativinas
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Affiliated Hospital of Nanjing University Medical School/CN
/
Affiliated Jiangsu University/CN
/
Affiliated Taicang Hospital of Traditional Chinese Medicine/CN
/
Jiangsu University Health Science Center, Yizheng Road, Zhenjiang/CN
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