Your browser doesn't support javascript.
loading
Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities
Wu, Ting; Wang, Meng; Wu, Wenfang; Luo, Qianxuan; Jiang, Liping; Tao, Huai; Deng, Meichun.
  • Wu, Ting; Central South University. School of Life Sciences. Department of Biochemistry and Molecular Biology. Changsha. CN
  • Wang, Meng; Central South University. School of Life Sciences. Department of Biochemistry and Molecular Biology. Changsha. CN
  • Wu, Wenfang; Central South University. School of Life Sciences. Department of Biochemistry and Molecular Biology. Changsha. CN
  • Luo, Qianxuan; Central South University. School of Life Sciences. Department of Biochemistry and Molecular Biology. Changsha. CN
  • Jiang, Liping; Central South University. Xiangya School of Medicine. Department of Parasitology. Changsha. CN
  • Tao, Huai; Hunan University of Chinese Medicine. Department of Biochemistry and Molecular Biology. Changsha. CN
  • Deng, Meichun; Central South University. School of Life Sciences. Department of Biochemistry and Molecular Biology. Changsha. CN
J. venom. anim. toxins incl. trop. dis ; 25: e146318, 2019. tab, graf, ilus
Artigo em Inglês | LILACS, VETINDEX | ID: biblio-1012632
ABSTRACT
Spider venoms are known to contain proteins and polypeptides that perform various functions including antimicrobial, neurotoxic, analgesic, cytotoxic, necrotic, and hemagglutinic activities. Currently, several classes of natural molecules from spider venoms are potential sources of chemotherapeutics against tumor cells. Some of the spider peptide toxins produce lethal effects on tumor cells by regulating the cell cycle, activating caspase pathway or inactivating mitochondria. Some of them also target the various types of ion channels (including voltage-gated calcium channels, voltage-gated sodium channels, and acid-sensing ion channels) among other pain-related targets. Herein we review the structure and pharmacology of spider-venom peptides that are being used as leads for the development of therapeutics against the pathophysiological conditions including cancer and pain.(AU)
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Peptídeos / Venenos de Aranha / Analgésicos / Neoplasias / Antineoplásicos Idioma: Inglês Revista: J. venom. anim. toxins incl. trop. dis Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Central South University/CN / Hunan University of Chinese Medicine/CN

Similares

MEDLINE

...
LILACS

LIS


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Peptídeos / Venenos de Aranha / Analgésicos / Neoplasias / Antineoplásicos Idioma: Inglês Revista: J. venom. anim. toxins incl. trop. dis Ano de publicação: 2019 Tipo de documento: Artigo Instituição/País de afiliação: Central South University/CN / Hunan University of Chinese Medicine/CN