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Analysis of the combined effects of resveratrol and radiation on lung cancer cells
Moreno, Carolina S; Rogero, Sizue O; Galisteo, André J; Vieira, Daniel P.
  • Moreno, Carolina S; Instituto de Pesquisas Energéticas e Nucleares. BR
  • Rogero, Sizue O; Instituto de Pesquisas Energéticas e Nucleares. BR
  • Galisteo, André J; Universidade de São Paulo. BR
  • Vieira, Daniel P; Instituto de Pesquisas Energéticas e Nucleares. BR
Integrative Cancer Biology & Research ; 1(005): 2-27, 2017. tab, graf
Artigo em Inglês | SES-SP, LILACS, SESSP-IALPROD, SES-SP, SESSP-IALACERVO | ID: biblio-1016912
ABSTRACT
Mucoepidermoid lung carcinoma is frequently manifested by obstructive trachea symptoms. It is necessary to develop effective curative or palliative therapeutic strategies for treating mucoepidermoid lung carcinoma through administration of compounds that improve ionizing radiation treatment, thereby increasing the effects of the treatment on tumor cells while minimizing the effects on normal tissues surrounding the tumor cells. Resveratrol is a polyphenolic phytoalexin present in wines and several plants and has a broad spectrum of biological activities, including antioxidant and anticarcinogenic effects. The biological effects of ionizing radiation plus resveratrol have been examined in different types of cell in many studies. Here, we aimed to verify the effects of resveratrol on mucoepidermoid lung carcinoma cells NCI-H292 exposed to ionizing radiation. In vitro studies in NCI-H292 cell culture using neutral red uptake assays showed that the cytotoxicity index (IC50) of resveratrol was 401.5 µM, and the lethal dose 50 % (LD50) of ionizing radiation in the absence of resveratrol was 693 Gy. In vitro micronucleus...(AU)
Assuntos
Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Radiação / Radiação Ionizante / Fluorescência / Neoplasias Pulmonares Idioma: Inglês Revista: Integrative Cancer Biology & Research Ano de publicação: 2017 Tipo de documento: Artigo Instituição/País de afiliação: Instituto de Pesquisas Energéticas e Nucleares/BR / Universidade de São Paulo/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Radiação / Radiação Ionizante / Fluorescência / Neoplasias Pulmonares Idioma: Inglês Revista: Integrative Cancer Biology & Research Ano de publicação: 2017 Tipo de documento: Artigo Instituição/País de afiliação: Instituto de Pesquisas Energéticas e Nucleares/BR / Universidade de São Paulo/BR