Pinhal virus, a new arenavirus isolated from calomys tener in Brazil
Vector Borne Zoonotic Dis
;
15(11): 694-700, 2015.
Artigo
em Inglês
| LILACS, SES-SP, SESSP-IALPROD, SES-SP, SESSP-IALACERVO
| ID: biblio-1022067
ABSTRACT
Arenavirus Sabiá was originally isolated from a fatal human infection in Brazil, and after the occurrence of the second fatal human case in São Paulo state, epidemiologic and virologic studies were performed in the area where the patient lived, aiming at the identification of the Sabiá natural rodent reservoir. A broadly cross-reactive enzyme-linked immunosorbent assay (ELISA) was used to screen for antibody-positive samples. Antibodies to arenavirus were detected in two of the 55 samples of Calomys tener, and from these results, samples of rodents were analyzed by a broad RT-PCR assay. RT-PCR amplification detected arenavirus sequences in five of the 55 C. tener samples, and sequencing showed that this virus is a distinct form of Sabiá virus. Thus, we describe here the evidence for the circulation of a new arenavirus in Brazil (proposed name Pinhal virus) and its genetic characterization compared to other arenaviruses. This study also suggests C. tener as a probable rodent reservoir for this virus and associates this new virus with the lineage C of New World arenaviruses. Although we have defined some characteristics of this virus, so far, there is no evidence of its involvement in human disease.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Filogenia
/
Brasil
/
Reservatórios de Doenças
/
Ensaio de Imunoadsorção Enzimática
/
Sigmodontinae
/
Arenavirus do Novo Mundo
/
Infecções por Arenaviridae
/
Animais
/
Anticorpos Antivirais
Tipo de estudo:
Estudo prognóstico
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Vector Borne Zoonotic Dis
Ano de publicação:
2015
Tipo de documento:
Artigo
Instituição/País de afiliação:
Faculdade de Medicina de Ribeirão Preto/BR
/
Insituto Nacional de Enfermedades Virales Humanas Dr. Julio I. Maiztegui-Pergamino/AR
/
Secretaria da Saúde do Estado de São Paulo/BR
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