Enhanced apoptosis and inhibition of gastric cancer cell invasion following treatment with LDH@Au loaded Doxorubicin
Electron. j. biotechnol
; Electron. j. biotechnol;32: 13-18, Mar. 2018. ilus, graf
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| ID: biblio-1022495
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ABSTRACT
Background:
The suppression of cancer cell growth and invasion has become a challenging clinical issue. In this study, we used nanotechnology to create a new drug delivery system to enhance the efficacy of existing drugs. We developed layered double hydroxide by combing Au nanosol (LDH@Au) and characterized the compound to prove its function as a drug delivery agent. The anti-cancer drug Doxorubicin was loaded into the new drug carrier to assess its quality. We used a combination of apoptosis assays, cell cycle assays, tissue distribution studies, cell endocytosis, transwell invasion assays, and immunoblotting to evaluate the characteristics of LDH@Au as a drug delivery system.Results:
Our results show that the LDH@Au-Dox treatment significantly increased cancer cell apoptosis and inhibited cell invasion compared to the control Dox group. Additionally, our data indicate that LDH@Au-Dox has a better target efficiency at the tumor site and improved the following cellular uptake, anti-angiogenesis action, changes in the cell cycle, and increased caspase pathway activation.Conclusions:
Our findings suggest the nano drug is a promising anti-cancer agent and has potential clinical applications.Palavras-chave
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LILACS
Assunto principal:
Neoplasias Gástricas
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Doxorrubicina
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Apoptose
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Nanopartículas
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Antibióticos Antineoplásicos
Idioma:
En
Revista:
Electron. j. biotechnol
Assunto da revista:
BIOTECNOLOGIA
Ano de publicação:
2018
Tipo de documento:
Article