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Desmoplastic fibroma of the mandible: a rare gnathic bone tumor with a review of the literature
Madakshira, Manoj Gopal; Bal, Amanjit; Verma, Roshan Kumar.
  • Madakshira, Manoj Gopal; Post Graduate Institute and Medical Education and Research. Department of Histopathology. Chandigarh. IN
  • Bal, Amanjit; Post Graduate Institute and Medical Education and Research. Department of Histopathology. Chandigarh. IN
  • Verma, Roshan Kumar; Post Graduate Institute and Medical Education and Research. Department of Otolaryngology and Head & Neck Surgery. Chandigarh. IN
Autops. Case Rep ; 9(4): e2019091, Oct.-Dec. 2019. ilus, tab
Artigo em Inglês | LILACS | ID: biblio-1024295
ABSTRACT
Desmoplastic fibroma (DF) is a rare bone tumor, which is known to involve mostly the gnathic bones. In this setting, the clinical presentation is usually represented by a bulging tumor of the face. Radiologically, the tumor is usually characterized by an expansile lytic bone lesion. The histopathology of the tumor shows a poorly circumscribed hypocellular lesion rich in collagen fibers with interspersed spindle cells having bland nuclear chromatin. Despite the lack of mitoses and nuclear pleomorphism, DF has an aggressive nature, presenting as a destructive growth causing entrapment of neuro-vascular bundles, sinusitis, or trismus. Some cases of DF show mutations in the adenomatous polyposis coli pathway shown by nuclear localization of the ß-catenin protein. Few reports showed an association with tuberous sclerosis, though most of these cases were sporadic. We discuss a rare case of desmoplastic fibroma involving the mandible, and a review of the literature of the DF cases involving the gnathic bones.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Neoplasias Ósseas / Fibroma Desmoplásico Limite: Criança, pré-escolar / Feminino / Humanos Idioma: Inglês Revista: Autops. Case Rep Assunto da revista: Anatomia / Patologia Cl¡nica / Patologia Legal Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Post Graduate Institute and Medical Education and Research/IN

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Neoplasias Ósseas / Fibroma Desmoplásico Limite: Criança, pré-escolar / Feminino / Humanos Idioma: Inglês Revista: Autops. Case Rep Assunto da revista: Anatomia / Patologia Cl¡nica / Patologia Legal Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Índia Instituição/País de afiliação: Post Graduate Institute and Medical Education and Research/IN