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Short-term use of resveratrol in alloplastic graft material applied with calvarial bone defects in rats
Laçin, Nihat; Deveci, Engin.
Afiliação
  • Laçin, Nihat; University of Katip Çelebi. Faculty of Dentistry. Department of Oral and Maxillofacial Surgery. İzmir. TR
  • Deveci, Engin; Dicle University. Faculty of Medicine. Department of Histology and Embryology. Diyarbakir. TR
Acta cir. bras ; Acta cir. bras;34(7): e201900704, 2019. tab, graf
Article em En | LILACS | ID: biblio-1038112
Biblioteca responsável: BR1.1
ABSTRACT
Abstract

Purpose:

The effects of resveratrol administration on calvarial bone defects with alloplastic graft material was investigated for osteoinductive reaction and bone development in rats.

Methods:

Healthy male rats were randomly divided into 3 groups consisting of 10 rats. Groups were as follows control (defect) group, defect + graft group, and defect + graft + resveratrol group. A calvarial bone defect was created in all groups, alloplastic bone grafts were applied to the defect in the 2nd and 3rd group, resveratrol (5 mg/kg/day) was added to the drinking water of the animals following graft application for 28 days in the 3rd group.

Results:

Increase in osteoclasts and necrotic changes were observed histopathologically in the control group. In the 2nd group, reduction of inflammation, congestion of blood vessels, increased osteblastic activity, osteoinductive effect, progression of osteocyte development and increased collagen fibers in connective tissue were observed. In the 3rd group, osteoblasts seemed to secrete bone matrix and accelerate osteoinductive effect with increased osteopregenitor activity and positive osteopontin and osteonectin expressions.

Conclusion:

Resveratrol treatment was thought to be an alternative and supportive drug for implant application by inducing new bone formation in the calvaral defect region as a result of short-term treatment.
Assuntos
Palavras-chave

Texto completo: 1 Índice: LILACS Assunto principal: Crânio / Regeneração Óssea / Transplante Ósseo / Substitutos Ósseos / Resveratrol Limite: Animals Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Índice: LILACS Assunto principal: Crânio / Regeneração Óssea / Transplante Ósseo / Substitutos Ósseos / Resveratrol Limite: Animals Idioma: En Revista: Acta cir. bras Assunto da revista: Cirurgia Geral / Procedimentos Cir£rgicos Operat¢rios Ano de publicação: 2019 Tipo de documento: Article