Smaller left anterior cingulate cortex in non-bipolar relatives of patients with bipolar disorder
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 41(3): 254-256, May-June 2019. tab
Article
em En
| LILACS
| ID: biblio-1039095
Biblioteca responsável:
BR1.1
ABSTRACT
Objective:
Bipolar disorder (BD) is highly heritable. The present study aimed at identifying brain morphometric features that could represent markers of BD vulnerability in non-bipolar relatives of bipolar patients.Methods:
In the present study, structural magnetic resonance imaging brain scans were acquired from a total of 93 subjects, including 31 patients with BD, 31 non-bipolar relatives of BD patients, and 31 healthy controls. Volumetric measurements of the anterior cingulate cortex (ACC), lateral ventricles, amygdala, and hippocampus were completed using the automated software FreeSurfer.Results:
Analysis of covariance (with age, gender, and intracranial volume as covariates) indicated smaller left ACC volumes in unaffected relatives as compared to healthy controls and BD patients (p = 0.004 and p = 0.037, respectively). No additional statistically significant differences were detected for other brain structures.Conclusion:
Our findings suggest smaller left ACC volume as a viable biomarker candidate for BD.Palavras-chave
Texto completo:
1
Índice:
LILACS
Assunto principal:
Transtorno Bipolar
/
Giro do Cíngulo
/
Hipocampo
Tipo de estudo:
Observational_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Assunto da revista:
PSIQUIATRIA
Ano de publicação:
2019
Tipo de documento:
Article