Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury
Clinics
;
72(10): 645-648, Oct. 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1039533
ABSTRACT
OBJECTIVES:
Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage.METHODS:
We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection.RESULTS:
We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed.CONCLUSION:
We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of intestinal damage in such situations.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pressão Venosa
/
Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Hepatectomia
/
Mucosa Intestinal
/
Neoplasias Hepáticas
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital Sírio-Libanês/BR
/
Universidade de São Paulo/BR
Similares
MEDLINE
...
LILACS
LIS