Reduction of venous pressure during the resection of liver metastases compromises enteric blood flow: IGFBP-1 as a novel biomarker of intestinal barrier injury
Clinics
;
72(10): 645-648, Oct. 2017. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1039533
ABSTRACT
OBJECTIVES: Disruption of the intestinal barrier and bacterial translocation commonly occur when intestinal blood flow is compromised. The aim of this study was to determine whether liver resection induces intestinal damage. METHODS: We investigated intestinal fatty-acid binding protein and insulin-like growth factor binding protein levels in the plasma of patients who underwent liver resection. RESULTS: We show that liver resection is associated with significant intestinal barrier injury, even if the Pringle maneuver is not performed. CONCLUSION: We propose the use of insulin-like growth factor binding protein-1 as a novel biomarker of intestinal damage in such situations.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pressão Venosa
/
Proteína 1 de Ligação a Fator de Crescimento Semelhante à Insulina
/
Hepatectomia
/
Mucosa Intestinal
/
Neoplasias Hepáticas
Limite:
Adulto
/
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Clinics
Assunto da revista:
Medicina
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Hospital Sírio-Libanês/BR
/
Universidade de São Paulo/BR
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