Subversion of immunoproteasome subunit expression in dengue virus serotype 2-infected HepG2 cells
Rev. Soc. Bras. Med. Trop
;
50(1): 99-103, Jan.-Feb. 2017. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1041391
ABSTRACT
Abstract: INTRODUCTION: Infection with all serotypes of dengue virus (DV) results in augmented antigen presentation by MHC class I molecules. However, the upregulation of immunoproteasome subunits only results from infection with two serotypes. This study aims to elucidate changes in the expression of immunoproteasome subunits resulting from infection with DV, particularly DV serotype 2 (DV2). METHODS: HepG2 cells were grown in various culture milieu. Total cellular RNA and proteins were extracted and quantified. RESULTS: Results demonstrated sequestration of immunoproteasome subunits LMP2 and LMP7 in DV2-infected cells. CONCLUSIONS: This study provides insights into the mechanisms underlying immune evasion by DV.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Vírus da Dengue
/
Complexo de Endopeptidases do Proteassoma
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Malásia
Instituição/País de afiliação:
University of Malaya/MY
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