Ex vivo T-lymphocyte chemokine receptor phenotypes in patients with chronic Chagas disease
Rev. Soc. Bras. Med. Trop
;
50(5): 689-692, Sept.-Oct. 2017. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1041423
ABSTRACT
Abstract INTRODUCTION:
Elucidating the molecules involved in the inflammatory process of chronic Chagas disease may allow identification of treatment targets.METHODS:
The ex vivo phenotypic expression of chemokine receptors CCR1, CCR3, CCR4, CCR5, CXCR2, CXCR3, CXCR4, and CXCR5 on the CD4+ and CD8+ T-cells of patients with chronic Chagas cardiomyopathy of varying severity was evaluated using flow cytometry.RESULTS:
Differential expression of CD4+CCR3+ and CD8+CCR4+ T-cells was observed in patients with mild cardiac involvement compared, respectively, with patients with severe cardiac and asymptomatic forms of Chagas disease.CONCLUSIONS:
These receptors are possibly involved in the pathogenesis of chronic Chagas cardiomyopathy.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Linfócitos T CD4-Positivos
/
Cardiomiopatia Chagásica
/
Linfócitos T CD8-Positivos
/
Receptores CCR
Limite:
Idoso
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2017
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Faculdade Pernambucana da Saúde/BR
/
Fundação Oswaldo Cruz/BR
/
Universidade de Pernambuco/BR
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