Antiplasmodial and antileishmanial activities of compounds from Piper tuberculatum Jacq fruits
Rev. Soc. Bras. Med. Trop
;
51(3): 382-386, Apr.-June 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1041466
ABSTRACT
Abstract INTRODUCTION This study assessed the activity of compounds from Piper tuberculatum against Plasmodium falciparum and Leishmania guyanensis. METHODS The effects of compounds from P. tuberculatum fruits on P. falciparum and L. guyanensis promastigote growth in vitro were determined. Hemolytic action and cytotoxicity in HepG2 and J774 cells were measured. RESULTS Three compounds showed strong antiplasmodial activity and one compound showed strong antileishmanial activity. Two compounds were non-toxic to HepG2 cells and all were toxic to J774 cells. The compounds showed no hemolytic activity. CONCLUSIONS The tested compounds from P. tuberculatum exhibited antiparasitic and cytotoxic effects.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Plasmodium falciparum
/
Extratos Vegetais
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Leishmania guyanensis
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Piper
/
Frutas
/
Antiprotozoários
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Faculdade de Educação e Cultura de Vilhena/BR
/
Fundação Oswaldo Cruz/BR
/
Fundação Universidade Federal de Rondônia/BR
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