Maternal schistosomiasis: IL-2, IL-10 and regulatory T lymphocytes to unrelated antigen in adult offspring mice
Rev. Soc. Bras. Med. Trop
;
51(4): 546-549, July-Aug. 2018. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1041472
ABSTRACT
Abstract INTRODUCTION:
We evaluated IL-10, IL-2 and regulatory T cells (Treg), in response to ovalbumin (OA), in offspring from schistosomotic mouse mothers.METHODS:
We used animals born (BIM) or suckled (SIM) from infected mothers; and mice born/suckled from infected (BSIM) or non-infected mothers (CONTROL). After OA+adjuvant immunization, spleen cells were cultured, with or without OA, and doubly marked for cytometry.RESULTS:
BIM showed fewer CD4+/IL-2+ and more B220+/IL-10+ cells, whereas the SIM group showed increased Treg frequency. BSIM had fewer B220+/IL-10+ and Treg cells.CONCLUSIONS:
Separately, gestation or nursing induced immunosuppressive cells in infected mothers, but improved anti-OA immunity when combined.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Esquistossomose mansoni
/
Anticorpos Anti-Helmínticos
/
Interleucina-2
/
Interleucina-10
/
Linfócitos T Reguladores
/
Animais Lactentes
Limite:
Animais
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Fundação Oswaldo Cruz/BR
/
Universidade Federal de Pernambuco/BR
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