Effect of artemisinin-piperaquine treatment on the electrocardiogram of malaria patients
Rev. Soc. Bras. Med. Trop
;
52: e20180453, 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1041531
ABSTRACT
Abstract INTRODUCTION: Concern regarding the cardiotoxicity of antimalarials has been renewed because of their potential to cause QT/QTc interval prolongation related to torsade de pointes (TdP). Artemisinin-piperaquine (AP) is considered an effective artemisinin-based combination therapy (ACT) for malaria. METHODS: This study involved a retrospective analysis of clinical data of 93 hospitalized malaria patients who had received AP orally. Electrocardiograms (ECGs) were obtained at specific time points in the original study. RESULTS: Some cases of QT prolongation were observed. However, no TdP was found. CONCLUSIONS: AP may cause QT interval prolongation in some malaria patients but may not lead to TdP.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Quinolinas
/
Síndrome do QT Longo
/
Malária Falciparum
/
Artemisininas
/
Antimaláricos
Tipo de estudo:
Estudo diagnóstico
/
Estudo observacional
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Guangzhou University of Chinese Medicine/CN
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