Stress conditions in the host induce persister cells and influence biofilm formation by Staphylococcus epidermidis RP62A
Rev. Soc. Bras. Med. Trop
;
52: e20180001, 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1041589
ABSTRACT
Abstract INTRODUCTION: Studies have demonstrated that pathogens react to the harsh conditions in human tissues by inducing mechanisms that promote survival. METHODS: Persistence and biofilm-forming ability were evaluated during stress conditions that mimic those in the host. RESULTS: Carbon-source availability had a positive effect on Staphylococcus epidermidis RP62A adhesion during hypoxia, accompanied by a decrease in pH. In contrast, iron limitation led to decreased surface-adherent biomass, accompanied by an increase medium acidification and lactate levels. Interestingly, iron starvation and hypoxia induced persister cells in planktonic culture. CONCLUSIONS: These findings highlight the role of host stress in the virulence of S. epidermidis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Staphylococcus epidermidis
/
Virulência
/
Biofilmes
/
Meios de Cultura
/
Interações entre Hospedeiro e Microrganismos
Limite:
Humanos
Idioma:
Inglês
Revista:
Rev. Soc. Bras. Med. Trop
Assunto da revista:
Medicina Tropical
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Federal de Goiás/BR
/
Universidade Federal de Mato Grosso do Sul/BR
/
Universidade de Brasília/BR
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