The High Flow Nasal Cannula Improves the Exercise Capacity in Patients with Chronic Obstructive Pulmonary Disease: Randomized, Crossover Clinical Trial
Rev. am. med. respir
;
19(1): 16-26, mar. 2019. ilus, graf, tab
Artigo
em Inglês
| LILACS
| ID: biblio-1041676
ABSTRACT
Introduction:
The effects of high flow nasal cannula (HFNC) such as reducing of work of breathing could improve exercise tolerance in stable chronic obstructive pulmonary disease (COPD) patients, however there is a great lack of evidence supporting its use.Aims:
To compare the maximum speed (MS) reached on an Incremental Exercise Test (IET) and Limit Time (Tlim) on a Constant Work Rate Exercise Test (CWRET) using High Flow Nasal Cannula (HFNC) vs Venturi Mask (VM). MethodsSubjects:
28 COPD patients (56% male, age mean 69 yr and FEV1 44% predicted) who require oxygen during exercise.Design:
randomized crossover trial. Variables MS, Tlim, symptoms, oxygen saturation (SpO2), heart rate, respiratory rate, blood pressure and comfort. Procedure Each patient performed two IET and two CWRET, one time using HFNC and the other with VM. Statisticanalysis:
we carried out a hypothesis contrast of paired data comparing MS, Tlim and physiological variables. p < 0.05 was considered statistically significant.Results:
HFNC vs MV increased MS (5,9 vs 5,7 km/h; p = 0.0002) and Tlim (450 vs 315 sec; p = 0.004), with higher SpO2 and less dyspnea (p < 0.05) at both isowork and isotime, with no statistically significant differences on confort.Conclusions:
HFNC improved exercise capacity in COPD patients increasing MS during IET and Tlim on CWRET with higher SpO2 and reduced dyspnea in comparison to VM. HFNC and VM were equally comfortable.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Oxigenoterapia
/
Reabilitação
/
Doença Pulmonar Obstrutiva Crônica
/
Cânula
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Idioma:
Inglês
Revista:
Rev. am. med. respir
Assunto da revista:
Medicina
/
Pneumologia
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Argentina
/
Espanha
Instituição/País de afiliação:
Hospital Clínic/ES
/
Hospital Italiano de Buenos Aires/AR
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