Characterization of the intestinal graft in a swine hypotensive after brain death model
Acta cir. bras
;
34(11): e201901107, Nov. 2019. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1054678
ABSTRACT
Abstract Purpose:
To establish a hypotensive brain death pig model and observe the effects of hypotension on small bowel donors.Methods:
The hypotensive brain death model was produced using the modified intracranial water sac inflation method in ten domestic crossbred pigs. Effects of hypotensive brain death on small bowel tissue morphology were evaluated through changes in intestinal tissue pathology, tight junction protein of the intestinal mucosa and plasma intestinal fatty acid-binding protein (i-FABP) levels. The pathophysiological mechanism was examined based on changes in superior mesenteric artery (SMA) blood flow and systemic hemodynamics.Results:
After model establishment, SMA blood flow, and the mean arterial pressure (MAP) significantly decreased, while heart rate increased rapidly and fluctuated significantly. Small bowel tissue morphology and levels of tight junction protein of the intestinal mucosa showed that after model establishment, small bowel tissue injury was gradually aggravated over time (P<0.05). Plasma i-FABP levels significantly increased after brain death (P<0.05).Conclusions:
A hypotensive brain death pig model was successfully established using an improved intracranial water sac inflation method. This method offers a possibility of describing the injury mechanisms more clearly during and after brain death.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Morte Encefálica
/
Modelos Animais de Doenças
/
Hipotensão
/
Intestino Delgado
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
China
Instituição/País de afiliação:
Linyi Municipal Mental Health Center/CN
/
Xuzhou Medical University/CN
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