Effect of norbixin-based poly(hydroxybutyrate) membranes on the tendon repair process after tenotomy in rats
Acta cir. bras
;
34(11): e201901101, Nov. 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1054681
ABSTRACT
Abstract Purpose:
To determine the efficacy of norbixin-based poly(hydroxybutyrate) (PHB) membranes for Achilles tendon repair.Methods:
Thirty rats were submitted to total tenotomy surgery of the right Achilles tendon and divided into two groups (control and membrane; n = 15 each), which were further subdivided into three subgroups (days 7, 14, and 21; n = 5 each). Samples were analyzed histologically.Results:
Histological analysis showed a significant reduction in inflammatory infiltrates on days 7, 14 (p < 0.0001 for both), and 21 (p = 0.0004) in the membrane group compared to that in the control group. There was also a significant decrease in the number of fibroblasts in the control group on days 7, 14 (p < 0.0001), and 21 (p = 0.0032). Further, an increase in type I collagen deposition was observed in the membrane group compared to that in the control group on days 7 (p = 0.0133) and 14 (p = 0.0107).Conclusion:
Treatment with norbixin-based PHB membranes reduces the inflammatory response, increases fibroblast proliferation, and improves collagen production in the tendon repair region, especially between days 7 and 14.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Poliésteres
/
Tendão do Calcâneo
/
Carotenoides
/
Tenotomia
/
Hidroxibutiratos
Tipo de estudo:
Estudos de avaliação
Limite:
Animais
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
IFPI/BR
/
UESPI/BR
/
UNIVAP/BR
/
Universidade Federal do Ceará/BR
/
Universidade Federal do Piauí/BR
/
Universidade do Vale do Paraíba/BR
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