New metallophamaceutic reduced renal injury induced by non-steroidal anti-inflammatory
Acta cir. bras
;
34(12): e201901201, 2019. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1054690
ABSTRACT
Abstract Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods Wistar rats were assigned into three groups (n=6 rats/group) Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of experiments, kidneys were removed for histological study, fractal dimension and lacunarity in all animals. Results At the histological examination, all animals (six animals - 100 %) in the NSAID group had membrane thickening and other changes (necrosis, acute tubular congestion and vascular congestion); on the other hand, only one animal (16.6 %) of the Rut-bpy group had congestion. The fractal dimension and lacunarity were greater in the control and Rut-bpy group than in NSAIDs group (p<0.05). Conclusion Rut-bpy may prevent renal histological changes in rats caused by meloxicam.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Compostos Organometálicos
/
Rutênio
/
Anti-Inflamatórios não Esteroides
/
Doadores de Óxido Nítrico
/
Meloxicam
/
Nefropatias
Tipo de estudo:
Estudos de avaliação
Limite:
Animais
Idioma:
Inglês
Revista:
Acta cir. bras
Assunto da revista:
Cirurgia Geral
/
Procedimentos Cir£rgicos Operat¢rios
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Centro Universitário Christus/BR
/
UFC/BR
/
UNICHRISTUS/BR
/
Universidade Federal do Ceará/BR
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