New insights of growth hormone (GH) actions from tissue-specific GH receptor knockouts in mice
Arch. endocrinol. metab. (Online)
;
63(6): 557-567, Nov.-Dec. 2019. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1055021
ABSTRACT
ABSTRACT In order to provide new insights into the various activities of GH in specific tissues, recent advances have allowed for the generation of tissue-specific GHR knockout mice. To date, 21 distinct tissue-specific mouse lines have been created and reported in 28 publications. Targeted tissues include liver, muscle, fat, brain, bone, heart, intestine, macrophage, pancreatic beta cells, hematopoietic stem cells, and multi-tissue "global". In this review, we provide a brief history and description of the 21 tissue-specific GHR knockout mouse lines. Arch Endocrinol Metab. 2019;63(6):557-67
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Receptores da Somatotropina
/
Hormônio do Crescimento
Tipo de estudo:
Estudo prognóstico
Limite:
Animais
Idioma:
Inglês
Revista:
Arch. endocrinol. metab. (Online)
Assunto da revista:
Endocrinologia
/
Metabolismo
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
Ohio University/US
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