Growth hormone in the tumor microenvironment
Arch. endocrinol. metab. (Online)
; 63(6): 568-575, Nov.-Dec. 2019. graf
Article
em En
| LILACS
| ID: biblio-1055025
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cancer stem cells, non-tumorous cells, stromal cells, immune-inflammatory cells, blood and lymphatic vascular network, and extracellular matrix. We review reports and present a hypothesis that postulates the involvement of growth hormone (GH) in field cancerization. We discuss GH contribution to TME, promoting epithelial-to-mesenchymal transition, accumulation of unrepaired DNA damage, tumor vascularity, and resistance to therapy. Arch Endocrinol Metab. 2019;63(6)568-75
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Texto completo:
1
Índice:
LILACS
Assunto principal:
Dano ao DNA
/
Resistencia a Medicamentos Antineoplásicos
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Hormônio do Crescimento Humano
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Transição Epitelial-Mesenquimal
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Microambiente Tumoral
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Neovascularização Patológica
Limite:
Humans
Idioma:
En
Revista:
Arch. endocrinol. metab. (Online)
Assunto da revista:
ENDOCRINOLOGIA
/
METABOLISMO
Ano de publicação:
2019
Tipo de documento:
Article