Soluble Human Leukocyte Antigen Molecules Detected in Orofacial Cleft Patients: A Case-Control Study
Pesqui. bras. odontopediatria clín. integr
;
20: e5096, 2020. tab
Artigo
em Inglês
| LILACS, BBO
| ID: biblio-1056880
ABSTRACT
Abstract Objective:
To compare soluble HLA-C and HLA-DR molecules present in the plasma of orofacial cleft and non-orofacial cleft populations. Material andMethods:
Orofacial cleft patients were recruited using an accidental sampling approach (n=15). Peripheral blood was collected from the participants and processed for Enzyme Linked Immunosorbent Assay (ELISA) against HLA-C and HLA-DR with specific antibodies. The absorbance was calculated utilizing ELISA reader. Data were statistically analyzed using an independent t-test to compare the disease and control groups.Results:
The levels of soluble HLA-C and HLA-DR were significantly higher in the diseased group compared to the control group (p<0.05).Conclusion:
The role of HLA molecules in non-communicable disease and congenital anomalies, particularly orofacial cleft, remains speculative despite the positive results of this study and those of previous investigations. It suggests that the variables examined may affect specific pathways involved in the pathogenesis of orofacial cleft, and predispose the individuals concerned to the oral cleft.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Antígenos HLA-C
/
Antígenos HLA-DR
/
Estudos de Casos e Controles
/
Patogenesia Homeopática
/
Fenda Labial
Tipo de estudo:
Estudo observacional
Limite:
Adolescente
/
Criança
/
Feminino
/
Humanos
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
Pesqui. bras. odontopediatria clín. integr
Assunto da revista:
Odontologia
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Indonésia
Instituição/País de afiliação:
Universitas Airlangga/ID
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