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Enfermedad por priones, encefalopatía espongiforme humana y enfermedad de Creutzfeldt-Jakob / Prion induced spongiform encephalopathy of Creutzfeldt-Jakob disease
Cartier-Rovirosa, Luis.
  • Cartier-Rovirosa, Luis; Universidad de Chile. Facultad de Medicina. Departamento de Ciencias Neurológicas Oriente. Santiago. CL
Rev. méd. Chile ; 147(9): 1176-1183, set. 2019. tab
Artigo em Espanhol | LILACS | ID: biblio-1058661
ABSTRACT
The infectious protein or prion (PrPSC) is a transmissible and replicable polypeptide, which arises from an abnormal folding of the PrP protein, by unknown mechanisms and without changes in the primary sequence of its amino acids. Its new spatial disposition arises from the substitution of its alpha helices by beta bands, which increase its structural stability, avoiding its complete proteolysis, resulting in a residual accumulation of prions. These prions induce the misfolding of normal PrP protein, generating their exponential increase, leading to a disturbance of neuronal homeostasis which results in the development of the fatal spongiform encephalopathy of the Creutzfeldt-Jakob disease (CJD). This is the most prevalent human prion disease, and 90% of cases are sporadic, suggesting the endogenous genesis of prions. There are different types of prions, identified based on the genetic variance of codon 129 amino acids of the prion protein. Meteonin (M) and Valine (V)), associated with the result of their enzymatic proteolysis, define prions type 1 (21 kDa) and type 2 (19 kDa). The Classical form of CJD produced by MM1 prion occurs in 70% of the cases. The Cerebellar form originated by the VV2 prion occurs in 15% of cases, the form with Kuru plates, associated with the prion MV2 occurs in 5%, and the Vacuolar, related to the MM2 prion occurs in 4%. CJD is always characterized by behavioral, motor, cognitive, and vision alterations and by findings in magnetic resonance imaging, electroencephalogram and cerebrospinal fluid that define each clinical and neuropathological form.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Príons / Síndrome de Creutzfeldt-Jakob / Doenças Priônicas Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Universidad de Chile/CL

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Príons / Síndrome de Creutzfeldt-Jakob / Doenças Priônicas Tipo de estudo: Estudo prognóstico Limite: Humanos Idioma: Espanhol Revista: Rev. méd. Chile Assunto da revista: Medicina Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Chile Instituição/País de afiliação: Universidad de Chile/CL