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Incidence of Cytomegalovirus Antigenemia in patients with autoimmune rheumatic diseases: a 3-year retrospective study
Santos, Rebeka Paulo; Reis-Neto, Edgard Torres dos; Pinheiro, Marcelo Medeiros.
  • Santos, Rebeka Paulo; Universidade Federal de São Paulo. Division of Rheumatology. São Paulo. BR
  • Reis-Neto, Edgard Torres dos; Universidade Federal de São Paulo. Division of Rheumatology. São Paulo. BR
  • Pinheiro, Marcelo Medeiros; Universidade Federal de São Paulo. Division of Rheumatology. São Paulo. BR
Adv Rheumatol ; 59: 18, 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1088599
ABSTRACT
Abstract

Objective:

To determine the incidence of positive CMV antigenemia (CMV-Ag) in patients with autoimmune rheumatic diseases (AIRD) and to describe the outcomes of these patients.

Methods:

From January 2011 to December 2014, a total of 443 patients with AIRD were enrolled in this retrospective analysis. Demographic, clinical and laboratory data, current clinical manifestations, organs affected by CMV infection, therapeutic management and outcomes were evaluated. The CMV-Ag was considered positive when one cell was detected at least.

Results:

CMV-Ag was requested in 70 (15.8%) patients with suspicious CMV infection and was positive in 24 (34.3%). The incidence rate of positive CMV-Ag was 4.97% (95% CI 3.1-7.4%). Systemic lupus erythematosus (SLE) (59%), followed by ANCA-related vasculitis (18.2%) and rheumatoid arthritis (9%) were the diseases more associated with positive CMV-Ag. At the time of CMV infection, SLE patients had moderate to severe disease activity, with high frequency of positive anti-dsDNA antibody (69.2%) and complement consumption (61.5%), as well as high doses of corticosteroids and use of immunosuppressants. The main CMV sites involved were lung (45.5%), bone marrow (40. 9%) and gut (27.3%). Mortality rate was 45.5%, especially in those with higher doses of daily oral corticosteroids (107 ±55.4 mg vs. 71.7 ±46.3 mg; p = 0.07) and lower number of lymphocytes (309 ± 368.2/mm3 vs. 821 ± 692.9/ mm3; p = 0.06).

Conclusions:

Our data showed high incidence of CMV-Ag in AIRD patients, particularly those with SLE and greater disease severity. In addition, it was observed high mortality in these patients, highlighting the CMV infection should be included in differential diagnosis.
Assuntos


Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Sístole / Pressão Sanguínea Tipo de estudo: Estudo de incidência / Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de São Paulo/BR

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Texto completo: DisponíveL Índice: LILACS (Américas) Assunto principal: Sístole / Pressão Sanguínea Tipo de estudo: Estudo de incidência / Estudo observacional / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Adv Rheumatol Assunto da revista: Artrite / Reumatologia Ano de publicação: 2019 Tipo de documento: Artigo País de afiliação: Brasil Instituição/País de afiliação: Universidade Federal de São Paulo/BR