Association of CYP2J2 polymorphism with susceptibility to psoriasis in Turkish population: a case-control study
An. bras. dermatol
;
95(1): 25-31, Jan.-Feb. 2020. tab
Artigo
em Inglês
| LILACS
| ID: biblio-1088722
ABSTRACT
Abstract Background:
Cytochrome P450 2J2 is mostly expressed in extrahepatic tissues; it metabolizes arachidonic acid to epoxyeicosatrienoic acids, with various cardio protective and anti-inflammatory effects. CYP2J2 polymorphism has been identified as a risk factor for cardiovascular diseases, but its association with psoriasis remains unknown.Objective:
To evaluate CYP2J2 polymorphism as a risk factor for psoriasis in the Turkish population.Methods:
There were 94 patients with psoriasis and 100 age- and sex-matched healthy controls included in the study. Detailed demographic and clinical characteristics were recorded, and Psoriasis Area and Severity Index (PASI) scores were calculated for psoriasis patients. Venous blood samples were collected from all the participants and CYP2J2 50G>T (rs890293) polymorphism was analyzed using polymerase chain reaction (PCR).Results:
Both T allele and TT + GT genotype frequencies were increased in psoriasis vulgaris patients compared to the control group (p = 0.024 and p = 0.029 respectively, OR = 2.82, 95% CI 1.11-7.15) No association between CYP2J2 polymorphism and clinical features of psoriasis was identified. Studylimitations:
A limited number of patients were included in the study.Conclusion:
CYP2J2 50G>T (rs890293) polymorphism was associated with an increased risk for PsV in the Turkish population.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Polimorfismo Genético
/
Psoríase
/
Sistema Enzimático do Citocromo P-450
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Estudo prognóstico
/
Fatores de risco
Limite:
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Ásia
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Turquia
Instituição/País de afiliação:
Ankara Numune Training and Research Hospital/TR
/
Ufuk University/TR
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