Acantholytic pityriasis rubra pilaris associated with topical use of imiquimod 5%: case report and literature review
An. bras. dermatol
;
95(1): 63-66, Jan.-Feb. 2020. graf
Artigo
em Inglês
| LILACS
| ID: biblio-1088728
ABSTRACT
Abstract Topical use of immune response modifiers, such as imiquimod, has increased in dermatology. Although its topical use is well tolerated, it may be associated with exacerbations of generalized cutaneous inflammatory diseases, possibly through the systemic circulation of pro-inflammatory cytokines. This report describes a case of development of pityriasis rubra pilaris, a rare erythematous-papulosquamous dermatosis, in a woman aged 60 years during treatment with imiquimod 5% cream for actinic keratosis. It evolved with erythrodermic conditions and palmoplantar keratoderma, presenting progressive clinical resolution after the introduction of methotrexate. The authors emphasize the importance of recognizing possible systemic reactions associated with the topical use of imiquimod.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Pitiríase Rubra Pilar
/
Ceratose Actínica
/
Imiquimode
/
Antineoplásicos
Tipo de estudo:
Fatores de risco
Limite:
Feminino
/
Humanos
Idioma:
Inglês
Revista:
An. bras. dermatol
Assunto da revista:
Dermatologia
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Dermoclínica/BR
/
Universidade Estadual de Campinas/BR
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