Relationship of anti-tuberculosis drug-induced liver injury and genetic polymorphisms in CYP2E1 and GST
Braz. j. infect. dis
; Braz. j. infect. dis;23(6): 381-387, Nov.-Dec. 2019. tab, graf
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| LILACS
| ID: biblio-1089317
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Setting:
Treatment of tuberculosis (TB) can result in Drug-Induced Liver Injury (DILI) since hepatotoxic metabolites are formed during the biotransformation of isoniazid (INH).DILI can be related to the genetic profile of the patient. Single nucleotide polymorphisms in the CYP2E1 gene and GSTM1 and GSTT1 deletion polymorphisms have been associated with adverse events caused by INH.Objective:
To characterize the genetic polymorphisms of CYP2E1, GSTT1 and GSTM1 in TB carriers.Design:
This is an observational prospective cohort study of 45 patients undergoing treatment of TB. PCR-RFLP and multiplex-PCR were used.Results:
The distribution of genotypic frequency in the promoter region (CYP2E1 gene) was 98% wild genotype and 2% heterozygous. Intronic region 78% wild genotype; 20% heterozygous and 2% homozygous variant. GST enzyme genes 24% Null GSTM1 and 22% Null GSTT1. Patients with any variant allele of the CYP2E1 gene were grouped in the statistical analyses.Conclusion:
Patients with the CYP2E1 variant genotype or Null GSTT1 showed higher risk of presenting DILI (p = 0.09; OR 4.57; 95% CI 0.75-27.6). Individuals with both genotypes had no increased risk compared to individuals with one genotype.Palavras-chave
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Índice:
LILACS
Assunto principal:
Tuberculose Pulmonar
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Predisposição Genética para Doença
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Doença Hepática Induzida por Substâncias e Drogas
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Antituberculosos
Tipo de estudo:
Observational_studies
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Risk_factors_studies
Limite:
Adolescent
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Adult
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Aged
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Aged80
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Female
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Humans
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Male
Idioma:
En
Revista:
Braz J Infect Dis
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Braz. j. infect. dis
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Braz. j. infect. dis. (Online)
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Brazilian journal of infectious diseases (Impresso)
Assunto da revista:
DOENCAS TRANSMISSIVEIS
Ano de publicação:
2019
Tipo de documento:
Article