Presence of Type 1 Collagen Alpha-2 (COL1A2) (rs42524) Gene Polymorphism and Scar Tissue Formation in Different Areas of Head and Neck
Pesqui. bras. odontopediatria clín. integr
;
20: e4422, 2020. tab
Artigo
em Inglês
| BBO, LILACS
| ID: biblio-1101295
ABSTRACT
Abstract Objective:
To determine the effect type I collagen gene polymorphism alpha-2 (COL1A2) (rs42524) on the formation of scar tissue that is localized in the head and neck areas. Material andMethods:
Sixty patients with scars in different areas of the head and neck were examined. The patients were divided into four subgroups, according to the types of scarring G I 15 patients with normotrophic scars; G ІІ 15 patients with atrophic scars; G ІІІ 15 patients with hypertrophic scars; and G IV 15 patients with keloid scars. The age of patients ranged from 17 to 54 years. The single-nucleotide polymorphic site of the COL1A2 (rs42524) gene was detected by a polymerase chain reaction and subsequent analysis of restriction fragment lengths. Pearson's chi-squared test with Yates's correction and Fischer's exact test were used.Results:
There were no significant changes between the control and basic groups (p=0.83) at analyzing the frequencies of G and C alleles. For the G allele, the calculation of odds ratio between the basic and control groups was 0.93 at 95% confidence interval (CI) (0.50-1.75), for the C allele - OR was 1.07 at 95% CI (0.57-2.01).Conclusion:
Our studies may indirectly indicate the activation of the skin's protective reaction to physiological scarring and dosed scar formation in different areas of the head and neck.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Polimorfismo Genético
/
Reação em Cadeia da Polimerase
/
Cicatriz Hipertrófica
/
Colágeno Tipo I
/
Cabeça
Limite:
Adolescente
/
Adulto
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
Europa
Idioma:
Inglês
Revista:
Pesqui. bras. odontopediatria clín. integr
Assunto da revista:
Odontologia
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Ucrânia
Instituição/País de afiliação:
Ukrainian Medical Stomatological Academy/UA
/
Uzhgorod National University/UA
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