In vitro and in vivo antimalarial activity of the volatile oil of Cyperus articulatus (Cyperaceae)
Acta amaz
;
49(4): 334-342, out. - dez. 2019.
Artigo
em Inglês
| LILACS
| ID: biblio-1118972
ABSTRACT
Malaria is a disease of global tropical distribution, being endemic in more than 90 countries and responsible for about 212 million cases worldwide in 2016. To date, the strategies used to eradicate this disease have been ineffective, without specific preventive measures such as vaccines. Currently, the existing therapeutic arsenal is limited and has become ineffective against the expansion of artemisinin-resistant Plasmodium, demonstrating the need for studies that would allow the development of new compounds against this disease. In this context, we studied the volatile oil obtained from rhizomes of Cyperus articulatus (VOCA), a plant species commonly found in the Amazon region and popularly used as a therapeutic alternative for the treatment of malaria, in order to confirm its potential as an antimalarial agent by in vitro and in vivo assays. We cultured Plasmodium falciparum W2 (chloroquine-resistant) and 3D7 (chloroquine-sensitive) strains in erythrocytes and exposed them to VOCA at different concentrations in 96-well microplates. In vivo antimalarial activity was tested in BALB/c mice inoculated with approximately 106 erythrocytes infected with Plasmodium berghei. VOCA showed a high antimalarial potential against the two P. falciparum strains, with IC50 = 1.21 µg mL-1 for W2 and 2.30 µg mL-1 for 3D7. VOCA also significantly reduced the parasitemia and anemia induced by P. berghei in mice. Our results confirmed the antimalarial potential of the volatile oil of Cyperus articulatus. (AU)
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Plasmodium berghei
/
Plasmodium falciparum
/
Cloroquina
/
Artemisininas
/
Malária
Idioma:
Inglês
Revista:
Acta amaz
Assunto da revista:
Ciência
Ano de publicação:
2019
Tipo de documento:
Artigo
País de afiliação:
Brasil
Instituição/País de afiliação:
Universidade Estadual de Campinas/BR
/
Universidade Federal de São João Del Rei/BR
/
Universidade Federal do Oeste do Pará/BR
/
Universidade Federal do Rio de Janeiro/BR
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