Gene expression of collagen type I alpha 2 and its relationship with dental fluorosis
J. oral res. (Impresa)
;
7(6): 232-235, ago. 1, 2018. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1120975
ABSTRACT
Objective: to compare the gene expression levels of collagen type I alpha 2 (COL1A2) in children with and without dental fluorosis. methods: cross-sectional study involving 92 children between 5 and 12 years of age. socio-demographic characteristics, the presence of dental fluorosis by means of the Thylstrup-Fejerskov index, and gene expression analysis of COL1A2 in peripheral blood samples by reverse transcription polymerase chain reaction (RT-PCR) assays, were described. for the descriptive analysis, measures of central tendency, dispersion and proportions were used. differences between the groups (p<0.05) were established by the student t-test. results: mean age was 8.6 (SD=1.9) years, 51.1 percent were female; 54 children were diagnosed with fluorosis and 38 without fluorosis; prevalence of dental fluorosis was 58.7 percent (95 percent CI: 48.4 percent -68.9 percent). gene expression of COL1A2 was statistically significantly lower (p<0.05) in the participants with dental fluorosis. conclusion: there are differences in the expression levels of the COL1A2 gene among the population under study. therefore, COL1A2 may be potentially involved in the development of dental fluorosis.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Colágeno Tipo I
/
Fluorose Dentária
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Fatores de risco
Limite:
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Masculino
País/Região como assunto:
América do Sul
/
Colômbia
Idioma:
Inglês
Revista:
J. oral res. (Impresa)
Assunto da revista:
Odontologia
Ano de publicação:
2018
Tipo de documento:
Artigo
País de afiliação:
Colômbia
Instituição/País de afiliação:
Universidad de Cartagena/CO
Similares
MEDLINE
...
LILACS
LIS