PER3 VNTR variant and susceptibility to smoking status/substance use disorder in a Turkish population
Arch. Clin. Psychiatry (Impr.)
;
47(3): 71-74, May-June 2020. tab
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1130985
ABSTRACT
Abstract Background Substance use and smoking exert devastating impact on sleep, especially hindering the ease of falling asleep, compromising the sleep maintenance, and distorting the sleep cycles. PERIOD genes are believed to play a role in individual differences in sleep timing by influencing circadian. Objective The aim of this study was to ascertain whether Per3 VNTR variant affects suspectibility of individuals to substance use disorder (SUD) and smoking status in a Turkish population. Methods A total of 549 subjects, including 212 SUD patients, 160 smoker, and 177 healthy controls, matched by ethnicity, age, and gender, were recruited in a case-control study. Genotyping of Per3 variant was performed using PCR method. Results When the SUD, smoker groups and controls were compared in terms of 5R/5R, 5R/4R, 4R/4R genotypes, no significant difference was observed. Besides, allele frequencies of Per3 VNTR were similar among the groups. Discussion Our data indicate that Per3 VNTR variant is not associated with the risk of SUD and smoking status in our population.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Tipo de estudo:
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Revista:
Arch. Clin. Psychiatry (Impr.)
Assunto da revista:
Psiquiatria
Ano de publicação:
2020
Tipo de documento:
Artigo
/
Documento de projeto
País de afiliação:
Turquia
Instituição/País de afiliação:
Bakirkoy Research and Training Hospital for Psychiatry, Neurology and Neurosurgery/TR
/
Gaziantep University/TR
/
Hitit University/TR
/
Istanbul University/TR
/
University of Health Sciences/TR
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