Follicular Lesions with Papillary Nuclear Characteristics: Differences in Chromatin Detected by Computerized Image Analysis
Arch. endocrinol. metab. (Online)
;
64(5): 630-635, Sept.-Oct. 2020. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1131133
ABSTRACT
ABSTRACT Objective:
Follicular lesions of the thyroid with papillary carcinoma nuclear characteristics are classified as infiltrative follicular variant of papillary thyroid carcinoma-FVPTC (IFVPTC), encapsulated/well demarcated FVPTC with tumour capsular invasion (IEFVPTC), and the newly described category "non-invasive follicular thyroid neoplasm with papillary-like nuclear features" (NIFTP) formerly known as non-invasive encapsulated FVPTC. This study evaluated whether computerized image analysis can detect nuclear differences between these three tumour subtypes. Materials andmethods:
Slides with histological material from 15 cases of NIFTP and 33 cases of FVPTC subtypes (22 IEFVPTC, and 11 IFVPTC) were analyzed using the Image J image processing program. Tumour cells were compared for both nuclear morphometry and chromatin textural characteristics.Results:
Nuclei from NIFTP and IFVPTC tumours differed in terms of chromatin textural features (grey intensity) mean (92.37 ± 21.01 vs 72.99 ± 14.73, p = 0.02), median (84.93 ± 21.17 vs 65.18 ± 17.08, p = 0.02), standard deviation (47.77 ± 9.55 vs 39.39 ± 7.18; p = 0.02), and coefficient of variation of standard deviation (19.96 ± 4.01 vs 24.75 ± 3.31; p = 0.003). No differences were found in relation to IEFVPTC.Conclusion:
Computerized image analysis revealed differences in nuclear texture between NIFTP and IFVPTC, but not for IEFVPTC.
Texto completo:
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Índice:
LILACS (Américas)
Assunto principal:
Neoplasias da Glândula Tireoide
/
Carcinoma Papilar
/
Carcinoma Papilar, Variante Folicular
/
Adenocarcinoma Folicular
Tipo de estudo:
Estudo observacional
Limite:
Humanos
Idioma:
Inglês
Revista:
Arch. endocrinol. metab. (Online)
Assunto da revista:
Endocrinologia
/
Metabolismo
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Brasil
/
Portugal
Instituição/País de afiliação:
Universidade Estadual de São Paulo/BR
/
Universidade do Porto/PT
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