Dystrophic muscle distribution in late-stage muscular dystrophy
Autops. Case Rep
;
10(4): e2020221, 2020. tab, graf
Artigo
em Inglês
| LILACS
| ID: biblio-1131856
ABSTRACT
There is scant information about the comprehensive distribution of dystrophic muscles in muscular dystrophy. Despite different clinical presentations of muscular dystrophy, a recent multi-center study concluded that phenotypic distribution of dystrophic muscles is independent of clinical phenotype and suggested that there is a common pattern of involved muscles. To evaluate this possibility, the present case report used cadaveric dissection to determine the whole-body distribution of fat-infiltrated, dystrophic muscles from a 72-year-old white male cadaver with adult-onset, late-stage muscular dystrophy. Severely dystrophic muscles occupied the pectoral, gluteal and pelvic regions, as well as the arm, thigh and posterior leg. In contrast, muscles of the head, neck, hands and feet largely appeared unaffected. Histopathology and a CT-scan supported these observations. This pattern of dystrophic muscles generally conformed with that described in the multi-center study, and provides prognostic insight for patients and the physicians treating them.
Texto completo:
DisponíveL
Índice:
LILACS (Américas)
Assunto principal:
Distrofias Musculares
Tipo de estudo:
Ensaio Clínico Controlado
/
Estudo prognóstico
Limite:
Idoso
/
Humanos
/
Masculino
Idioma:
Inglês
Revista:
Autops. Case Rep
Assunto da revista:
Anatomia
/
Patologia Cl¡nica
/
Patologia Legal
Ano de publicação:
2020
Tipo de documento:
Artigo
País de afiliação:
Estados Unidos
Instituição/País de afiliação:
Virginia Commonwealth University/US
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